A review of the function and organization of the CDKN2A/CDKN2B locus and its role in human health and disease”
The three spliced variants encode distinct proteins and are eminent. Two of the genes encode isoforms which are structurally related. The structurally related isoforms are known to generally function as CDK4 kinase inhibitors. This leaves only one transcript which is made up of an alternate first exon which is located at 20Kb (Simone Fulda, Heike Allgayer, Helga Rehder, 2009).
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